Buddy Mullins performed for many years with his family group, the Mullins. They were later rebranded as Mullins & Co. and again later as Sunday Drive. Mullins also sang lead for the Gaither Vocal Band from 1994-1995. For a couple of years, he reunited with former Mullins singer Paul Lancaster in a group called Everyday Driven.
After taking a break from full-time touring for more than a decade, Mullins joined the Booth Brothers in 2021 replacing the group's long-time lead singer (and one of the title brothers), Ronnie Booth. This move reunited Mullins again with Paul Lancaster.
Mullins has also written or co-written several Southern Gospel songs.